Skinfluence Moisturiser with Syn-Ake® is a non-perfumed anti-aging creams containing a synthetic snake venom called Syn-ake.
To measure the SYN®-AKE Age Killing Effect, the smoothing effect (Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers. Results showed up to 52% reduction of wrinkle size after 28 days application.
Syn-ake, a compound developed by Swiss pharmaceutical company Pentapharm, mimic a protein found in the venom of the temple viper and are said to smooth wrinkles. This active ingredient has been widely reported to help relaxing facial muscles with reduction in wrinkles.
Skinfluence Moisturiser with Syn-Ake® – How It Works?
Skinfluence Moisturiser with Syn-Ake® works to reduce these wrinkles including wrinkles on forehead and mouth wrinkles by keeping the skin in a relaxed state, achieving a Botox-like muscle relaxing effect.
Relaxing the facial muscles can also help prevent deeper expression lines, while smoothing skin in the process. Other than reducing wrinkle depth, it also increase skin firmness, smooth and revitalize the skin.
Facial expressions causes lines that are visible on our face. Frowning, lifting of eyebrows, laughing or pulling a face are some typical facial expressions that causes facial lines. As we age, these facial lines becomes permanent wrinkles forming on our forehead, around the eyes and lower lips.
SYN®-AKE is based on a synthetic tripeptide that mimics the effect of Waglerin1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. SYN®-AKE acts in a manner similar to that of Waglerin1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR).
As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed1.
Syn-ake Efficacy Tests
In a 28-day trial, Pentapharm measured the smoothing effect of Syn-ake-infused cream. Compared with a placeno, based on findings by the company, 67% of participants reported a decrease in muscle contraction. Their wrinkle size was also reduced by 52%2.
In vitro tests:
Syn-ake is found to be effective to get rid of forehead wrinkles. The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo. A cream was applied to the forehead twice daily during 28 days.
To measure the SYN®-AKE Age Killing Effect, the smoothing effect (Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers.
Results showed up to 52% reduction of wrinkle size after 28 days application.
Syn-ake Cream – The Botox Alternative?
Synake penetrates skin and blocks the nerve receptors bringing down the muscle movement. SYN®-AKE has been thoroughly tested and is considered to be appropriate for cosmetic applications.
Why resort to Botox if the same effect could be achieved with a topical product?
Start banishing Those Unsightly Wrinkles Now!
Skinfluence Moisturiser with Syn-Ake®
(1) McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein & JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap. 289:543-550.
(2) Los Angeles Times (May 03, 2009) – Anti-aging creams with synthetic snake venom.